Li et al., Com. Biol. 2020

Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring
J. Li, L. Zhang, L. Yu, I. Minami, S. Miyagawa, M. Hörning, J. Dong, J. Qiao, X. Qu, Y. Hua, Fujimoto, Y. Shiba, Y. Zhao, F. Tang, S. Miyagawa, Y. Chen, Y. Sawa, C. Tang, L. Liu
Comunications Biology, 3, 122, 2020
doi : 10.1038/s42003-020-0853-0

Brief Summary: ''HiPSC-derived cardiomyocytes can form three-dimensional self-organized tissue rings... the trained tissue show matured features including increased cardiac-specific gene expression, enhanced Ca2+-handling properties, an increased oxygen-consumption rate, and enhanced contractile force. A mathematical model interprets the origination, propagation, and long-term behavior of the findings.''