Li et al., Com. Biol. 2020

Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring
J. Li, L. Zhang, L. Yu, I. Minami, S. Miyagawa, M. Hörning, J. Dong, J. Qiao, X. Qu, Y. Hua, Fujimoto, Y. Shiba, Y. Zhao, F. Tang, S. Miyagawa, Y. Chen, Y. Sawa, C. Tang, L. Liu
Comunications Biology, 3, 122, 2020
doi : 10.1038/s42003-020-0853-0

Brief Summary: ''HiPSC-derived cardiomyocytes can form three-dimensional self-organized tissue rings... the trained tissue show matured features including increased cardiac-specific gene expression, enhanced Ca2+-handling properties, an increased oxygen-consumption rate, and enhanced contractile force. A mathematical model interprets the origination, propagation, and long-term behavior of the findings.''

Erben et al., Adv. Heal. Mat. 2020

Precision 3D-printed cell scaffolds mimicking native tissue composition and mechanics
A. Erben, M. Hörning, B. Hartmann, T. Becke, S.A. Eisler, A. Southan, S. Cranz, O. Hayden, N. Kneidinger, M. Königshoff, M. Lindner, G.E.M. Tovar, G. Burgstaller, H. Clausen-Schaumann, S. Sudhop and M. Heymann
Advanced Healthcare Materials, 200918, 2020
doi : 10.1002/adhm.202000918

Brief Summary: ''... Here, two‐photon stereolithography is adopted to print up to mm‐sized high‐precision 3D cell scaffolds at micrometer resolution with defined mechanical properties from protein‐based resins. By modifying the manufacturing process including two‐pass printing or post‐print crosslinking, high precision scaffolds with varying Young's moduli ranging from 7‐300 kPa are printed. This approach will allow for a systematic investigation of single‐cell and tissue dynamics in response to defined mechanical and bio‐molecular cues and is ultimately scalable to full organs.''

All computer graphics images are designed using Blender, a free and open source 3D creation suite (see Some images were partly generated using Matlab and were only embeded. Here are only a few of my hobby projects shown.

This image is based on an introductory tutorial (CG Boost). I have added a red wine glass. Here, I wanted to see how I can use gravity to let rigid bodies adjust to their environment in blender.
My first project following the tutorial of Blender Guru showing my personal interpretation of a donut and a well shaped coffee mug. The latter is an important tool to work efficiently in science. ;-)
This illustration highlights my Diploma thesis. I used the materials for Enceladus and the Cassini spacecraft that are available at the NASA homepage. It's simple, but nice.
This image is supposed to highlight the mechano-sensing of motile cells on rigid substrates. My kids called it the monster cell. I build it up from skratch and used a wave-let generator in blender.
Here I tried some new features in Blender 2.80 using Fresnel effects, emission shading, and noise texture mapping.
This graphic started as a project for a potential journal cover of a paper. A similar version of that graphic got published as a homepage banner for the Biophysical Journal in 2019.
An optical mapped cardiac tissue showing Calcium waves is shown. One spiral wave is trapped on an obstacle (black circle) and one target wave originates from a pair of electrodes.
The result of a short introduction of Blender to a student, who wants to create some impressive schemes for a paper.

Hörning et al. J. of Struct. Biol. 2020

Mineralized scale patterns on the cell periphery of the chrysophyte Mallomonas determined by comparative 3D Cryo-FIB SEM data processing
M. Hörning, A. Schertel, R. Schneider, M.-L. Lemloh, M. R. Schweikert, and I. M. Weiss
Journal for Structural Biology, 209, 107403, 2020
doi : 10.1016/j.jsb.2019.10.005

Brief Summary: ''Computational automated routines and principal component analysis of the experimentally extracted Mallomonas data created a realistic mathematical model based on the Fibonacci pattern theory. A complete in silico scale case of Mallomonas was reconstructed showing an optimized scale coverage on the cell surface.''

History of races

Date Event-Name  Swim  Bike  Run Time Rage Rall
2020/09/13 Jedermann-Triathlon Sindelfingen 00:09:32 00:54:57 00:22:18  1:26:46 31.  273.
400m 17 km 4 km
2019/09/08 Jedermann-Triathlon Sindelfingen 00:11:26 00:53:33 00:21:45  1:26:45 22.  211.
500m 17 km 4 km